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Pain Management for Total Knee Replacement

After Hospital Discharge

It is important that your pain is well managed and under control following discharge from hospital. The aim is to reduce your pain to a level that allows you to walk and perform activities of daily living soon after discharge without too much discomfort. Generally when you are resting, your knee should feel relatively comfortable, however you may experience an increase in pain with activities such as physiotherapy. Bending the knee is likely to be the most painful. Night pain and sleep disturbance may persist for several months but will steadily improve. Most patients will benefit from taking a balanced selection of pain medications including strong opioids during the first 2 to 6 weeks. Some patients will experience an increase in pain following discharge and will struggle to complete their physiotherapy.

If the pain becomes severe

  • Reduce your activity, rest and elevate the leg and apply ice packs.
  • Modify your exercises including physiotherapy that may be exacerbating the pain.
  • Take extra pain relief when needed to allow you to maintain your comfort and mobility
  • If you continue to experience severe pain contact us on 9386 3933

It is important that you understand what medications to use when you leave the hospital.


The First 2 weeks

  1. Paracetamol (Panadol, Panadol Osteo) daily on a regular basis
  2. Anti-Inflammatories (Mobic, Celebrex, Nurofen etc.) daily on a regular basis
  3. Lyrica twice a day or just at night. Should you experience side effects such as excessive drowsiness, you can reduce your dose or take only at night. If you do not tolerate this medication it can be stopped.
  4. Paexia SR (Slow release) twice daily until your mobility is not significantly affected by pain. The initial dose is usually 50mg twice daily. This may be increased for some patients up to a maximum of 200mg twice daily. Targin is an alternative which may be prescribed.
  5. Paexia IR (Immediate release) 50mg as needed up to four times daily. This does not last long but may be useful for rapid onset pain relief before or after exercise. Endone (Oxycodone) is an alternative, which may be prescribed.

After 2 weeks

  1. Continue PARACETAMOL (Panadol or Panadol Osteo) on a regular basis until you no longer need any other pain medication
  2. Stop taking regular ANTI-INFLAMMATORIES if you are coping well. If you feel that you need to continue taking these please discuss with your doctor.
  3. Stop taking LYRICA if your pain control is adequate and you no longer need PALEXIA. If pain at night is an issue it may be useful to continue taking Lyrica at night until this improves.
  4. Reduce or stop using the PALEXIA once your pain is under control.

If you are still having difficulties with pain management after two weeks please consult your surgeon or GP for further advice and assessment.


How to reduce or taper strong opioids

The aim is to reduce then stop these medications completely.  This should commence once you are no longer experiencing severe pain and should be done in a gradual manner.

  • Aim to reduce your daytime dose initially by about 25-50% per week until you are no longer taking any opioids during the day. If you experience setbacks you can temporarily increase your opioid use and start to reduce again when you feel ready, usually within a week.  It may be more difficult to cease at night and it is usually better to work on this once you have significantly reduced your daytime use.
  • Opioids have different durations of action, such as Palexia SR (slow release) and IR (immediate release). The SR tablet has a slower onset but lasts longer whereas the IR tablet works quickly but does not last long. Typically a SR tablet is prescribed twice a day to provide ‘background’ pain relief with the IR tablet available if this is insufficient or if pain ramps up after exercise (breakthrough pain). The SR tablet is usually continued until the IR tablets are no longer needed. However you may find a preference for one tablet over the other and provided you understand the difference between the tablets you should be able to judge which combination is better for you.
  • Side effects are very common at higher doses (please see chart). The SR tablets may have side effects that persist longer.
  • Taking opioids at night may help with obtaining a good night’s sleep which will help with daytime pain management as well.
  • Continuing or adding Lyrica at night may help you reduce your opioid requirements and assist with sleep however taking Lyrica during the day may make you feel drowsy and cause visual disturbance. This is fully reversible when you stop taking the medication.
  • Adding or substituting opioids with Tramadol or codeine preparations such as Panadeine Forte may help but be careful not to take both Panadeine Forte and Panadol as both contain paracetamol. Side effect such as nausea or constipation may also be a problem with these tablets.

 

For more information visit www.betterpainrelief.org

MEDICATIONDOSEDURATIONSIDE EFFECTS
PARACETAMOL
is a simple pain reliever taken on a regular basis to reduce your need for stronger medication.
1g x4 times per day6-12 weeks until needing no other pain medicationsNil serious within normal dosing
(do not exceed 4g per day)
ANTI-INFLAMMATORIES

(Mobic, Celebrex, Voltaren, Neurofen & Naprosyn)
Continue to take daily tor 2 weeks after surgery then stop.
Mobic
(Meloxicam)
15mg daily
2 weeks minimum



Up to 6 weeks OK but if > 6 weeks: Consult with GP
Stomach upset
Kidney problems
Internal bleeding (rare)
Take with a glass of milk or after a meal. Avoid if you have kidney disease, stomach ulcers, heart failure or previous allergic reaction
Celebrex 100-200mg twice daily
LYRICA (Pregabalin)
taken to reduce pain during your hospital stay as well as the risk of longer term pain after surgery.
25-75mg once or twice daily2-6 weeks

May be more useful at night
Drowsiness
Confusion
Visual changes
Constipation
TRAMAL SR (Tramadol)
is used for moderately strong pain.  It may suit some but not is not tolerated by all patients.
50-100mg twice daily2-6 weeksNausea

Confusion
(avoid if any history of seizures
OPIOIDS
PALEXIA SR
(Tapentadol)
(slow release)


PALEXIA IR
(Tapentadol)
(immediate release)
This is a newer painkiller for moderate to strong pain.



TARGIN (Oxycodone/Naloxone)
An alternative to Palexia.



ENDONE (Oxycodone) is a strong painkiller good to take before physiotherapy or when pain is not well controlled.
50-200mg twice daily



50mg every 6 hours as needed



1 tablet twice daily



5-10mg every 6 hours as needed
2-6 weeks usual


6-12 weeks less common


More than 12 weeks undesirable
ê
CONSULT WITH PAIN SPECIALIST





Quick onset lasting
~ 2hours
Short term
Nausea
Constipation
Dry mouth
Drowsiness
Confusion
Itch

Longer term
Increasing pain
Loss of effect of medication
Risk of infections
Chronic pain
Addiction
MEDICATION DOSE DURATION SIDE EFFECTS
PARACETAMOL

is a simple pain reliever taken on a regular basis to reduce your need for stronger medication.

 

1g x4 times per day 6-12 weeks until needing no other pain medications Nil serious within normal dosing

(do not exceed 4g per day)

ANTI-INFLAMMATORIES

(Mobic, Celebrex, Voltaren, Neurofen & Naprosyn)

Continue to take daily tor 2 weeks after surgery then stop.

Mobic

(Meloxicam)

15mg daily

2 weeks minimum

 

Up to 6 weeks OK but if > 6 weeks: Consult with GP

Stomach upset

Kidney problems

Internal bleeding (rare)

Take with a glass of milk or after a meal. Avoid if you have kidney disease, stomach ulcers, heart failure or previous allergic reaction

Celebrex 100-200mg twice daily
LYRICA (Pregabalin) taken to reduce pain during your hospital stay as well as the risk of longer term pain after surgery.

 

25-75mg once or twice daily 2-6 weeks

May be more useful at night

Drowsiness

Confusion

Visual changes

Constipation

TRAMAL SR (Tramadol) is used for moderately strong pain.  It may suit some but not is not tolerated by all patients.

 

50-100mg twice daily 2-6 weeks Nausea

Confusion

(avoid if any history of seizures

OPIOIDS
PALEXIA SR

(Tapentadol)

(slow release)

 

PALEXIA IR

(Tapentadol)

(immediate release)

This is a newer painkiller for moderate to strong pain.

 

TARGIN (Oxycodone/Naloxone)

An alternative to Palexia.

 

ENDONE (Oxycodone) is a strong painkiller good to take before physiotherapy or when pain is not well controlled.

 

50-200mg twice daily

 

 

50mg every 6 hours as needed

 

 

 

 

1 tablet twice daily

 

 

5-10mg every 6 hours as needed

2-6 weeks usual

 

6-12 weeks less common

 

More than 12 weeks undesirable

ê

CONSULT WITH PAIN SPECIALIST

 

 

 

 

 

Quick onset lasting

~ 2hours

Short term

Nausea

Constipation

Dry mouth

Drowsiness

Confusion

Itch

 

Longer term

Increasing pain

Loss of effect of medication

Risk of infections

Chronic pain

Addiction

 

 

For more information visit www.betterpainrelief.org

 

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(08) 9386 3015
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